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Platelet P 1, P 4 ‐Di (adenosine‐5 1) tetraphosphate (AP 4 A) in migraine patients before and during β‐adrenoceptor blockade
Author(s) -
WINTHER K.,
HEDMAN C.,
FLODGAARD H.
Publication year - 1990
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1990.tb01866.x
Subject(s) - propranolol , metoprolol , platelet , adenosine , migraine , granule (geology) , endocrinology , medicine , blockade , chemistry , pharmacology , receptor , biology , paleontology
. P 1 , P 4 ‐Di(adenosine‐5 1 ) tetraphosphate (AP 4 A) is a metabolically inactive nucleotide which can be released from platelet dense granules. This study was designed firstly, to investigate whether platelet content of AP 4 A was decreased in patients with classical migraine and secondly, whether the content of AP 4 A was changed by β‐adrenoceptor blockade. No significant difference in platelet dense granule content of AP 4 A, was observed between 10 migraine patients and 10 normal controls. Both metoprolol, a β 1 ‐selective blocker and propranolol, a non‐selective beta‐blocker significantly decreased the migraine attack rate. However, while propranolol significantly reduced the platelet content of AP 4 A, metoprolol did not. Therefore, the present data suggest that platelet dense granule release, as estimated by the content of AP 4 A is not of major importance in migraine.