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A circadian rhythm of serum osteocalcin levels in postmenopausal osteoporosis
Author(s) -
PIETSCHMANN P.,
RESCH H.,
WOLOSZCZUK W.,
WILLVONSEDER R.
Publication year - 1990
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1990.tb01861.x
Subject(s) - osteocalcin , medicine , endocrinology , circadian rhythm , parathyroid hormone , osteoporosis , morning , postmenopausal osteoporosis , bone remodeling , radioimmunoassay , chemistry , calcium , bone mineral , alkaline phosphatase , biochemistry , enzyme
. The serum levels of osteocalcin, a 49 amino acid bone matrix protein, have been found to be a specific biochemical parameter of bone formation. The aim of our study was to assess the variability of serum osteocalcin and parathyroid hormone levels in postmenopausal osteoporosis. In 16 patients with postmenopausal osteoporosis, serum levels of osteocalcin and parathyroid hormone were determined in 4‐hourly intervals by radioimmunoassay. Whereas the serum parathyroid hormone levels were similar throughout the day, the serum osteocalcin levels showed a circadian rhythm, with lowest levels in the morning and maximal levels during the night. These findings might suggest a circadian variation of bone formation in patients with postmenopausal osteoporosis.