Premium
Congestive heart failure: involvement of perivascular peptides reflecting activity in sympathetic, parasympathetic and afferent fibres
Author(s) -
EDVINSSON L.,
EKMAN R.,
HEDNER P.,
VALDEMARSSON S.
Publication year - 1990
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1990.tb01796.x
Subject(s) - medicine , calcitonin gene related peptide , endocrinology , substance p , heart failure , vasoactive intestinal peptide , neuropeptide y receptor , neuropeptide , sympathetic nervous system , pathophysiology , calcitonin , autonomic nervous system , heart rate , blood pressure , receptor
. In controls and in patients suffering from congestive heart failure (CHF) the circulating levels of catecholamines, neuropeptide Y‐like immunoreacti‐vity (NPY‐LI), vasoactive intestinal peptide‐LI (VIP‐LI), substance P‐LI (SP‐LI) and calcitonin gene‐related peptide‐LI (CGRP‐LI) markers of sympathetic, parasympathetic and sensory nervous systems, respectively, have been examined. There was a significant rise in the levels of noradrenaline, NPY‐LI and SP‐LI already in moderate CHF (New York Heart Association Stage I and II). In patients with severe CHF (NYHA Stage III and IV) the circulating levels of noradrenaline, adrenaline, NPY‐LI and SP‐LI were significantly increased. CGRP‐LI was not altered, despite the fact that this peptide co‐exists in many tissues with SP. There was no change in VIP‐LI. The pathophysiological significance of this pattern of reaction of circulating catecholamines and neuropeptides is unclear; however, the rise in SP‐LI may be a reaction to counterbalance the vasoconstrictive effects of the activation of the sympatho‐adrenal system.