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Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake
Author(s) -
PERROT N.,
NALPAS B.,
YANG C. S.,
BEAUNE P. H.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00273.x
Subject(s) - isozyme , cytochrome p450 , ethanol , drug , pharmacology , chemistry , biochemistry , medicine , enzyme
Abstract. Cytochromes P450 (P450) are a family of isozymes which play an important role in xenobiotic metabolism. The concentration of three P450 isozymes, namely P450‐IIEl(Alc),‐HIA(NF) and ‐IIC8‐10(MP) has been measured in human liver biopsies of patients with different alcohol and drug intake status. All these three P450s were expressed in all subjects. Ethanol intake increased P450‐IIEl(Alc) content with no effect on the content of the two other P450s. Drug intake (barbiturates) increased both P450‐IIIA(NF) and ‐IIC8‐10(MP) content without any effect on P450‐IIEl(Alc). This paper brought, at protein level, further evidence of the importance of environmental conditions on P450 isozyme pattern, and therefore, on drug metabolizing capacity of human liver.