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Role of the gastric phase in fat‐induced gallbladder contraction and cholecystokinin secretion in humans
Author(s) -
MASCLEE A. A. M.,
JANSEN J. B. M. J.,
DRIESSEN W. M. M.,
GEUSKENS L. M.,
LAMERS C. B. H. W.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00257.x
Subject(s) - cholecystokinin , medicine , cholescintigraphy , gastric emptying , gallbladder , endocrinology , endogeny , radioimmunoassay , gastroenterology , stomach , receptor
. The present study was undertaken to investigate the role of the gastric phase of fat‐induced gallbladder contraction and endogenous cholecystokinin (CCK) secretion in humans. Gallbladder emptying, measured by cholescintigraphy, and endogenous CCK secretion, measured by radioimmunoassay, were studied in healthy subjects after both intragastric and intra‐intestinal administration of corn oil. In addition, patients with partial gastrectomy were investigated to study the effect of accelerated gastric emptying. In the healthy subjects, intragastric administration of fat resulted in a significantly ( P < 0.05) later increase in plasma CCK levels (20 ± 2 min) compared to intraintestinal fat (5 ± 1 min). Similarly, the onset of gallbladder emptying was significantly ( P < 0.05) delayed after intragastric fat (20±2 min) compared to intestinal fat (10±1 min). In the healthy subjects the integrated plasma CCK response to intragastric fat was significantly ( P < 0.005‐ P < 0.01) reduced from 10 to 30 min. In the patients with partial gastrectomy the rise in plasma CCK (10 ± 1 min) and the onset of gallbladder emptying (15 ± 2 min) were in the same range after intra‐intestinal and intragastric fat. No significant differences in plasma CCK levels, integrated CCK response or gallbladder emptying were found in the patients according to the site of fat application. It is concluded that endogenous CCK secretion and gallbladder emptying in response to intragastric fat are significantly delayed in healthy subjects but not in patients with partial gastrectomy, in whom gastric emptying is accelerated. The main role of the stomach in the regulation of gallbladder contraction is by regulating the delivery of the stimulus to the intestine.