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Risk factors for coronary artery disease: a study comparing hypercholesterolaemia and hypertriglyceridaemia in angiographically characterized patients
Author(s) -
BREIER CH.,
PATSCH J. R.,
MÜHLBERGER V.,
DREXEL H.,
KNAPP E.,
BRAUNSTEINER H.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00253.x
Subject(s) - medicine , cholesterol , coronary artery disease , hypertriglyceridemia , triglyceride , coronary atherosclerosis , endocrinology , lipoprotein , lipoprotein lipase , high density lipoprotein , cardiology , adipose tissue
. Fifty‐two male patients undergoing coronary angiography were allocated to four groups each consisting of 13 subjects: group I had normal coronary arteries and patients in groups II‐IV exhibited coronary artery disease. In group II, plasma cholesterol was below 250 mg dl ‐1 and triglycerides below 160 mg dl ‐1 ; in group III, cholesterol was above 270 mg dl ‐1 and triglycerides under 160 mg dl ‐1 ; and in group IV, cholesterol was under 270 mg dl ‐1 and triglycerides above 180mgdl ‐1 . The hypertriglyceridaemic group IV had the highest coronary score. In addition, it had lowest lipoprotein lipase activity, lowest HDL‐cholesterol and lowest high‐density lipoproteins‐2 (HDL‐2) levels, suggesting that this type of hypertriglyceridaemia is caused—at least, in part—by lipoprotein lipase deficiency with impaired removal of the triglyceride‐rich lipoproteins and increased catabolism of HDL‐2. Our findings point towards a type of hypertriglyceridaemia strongly associated with coronary artery disease which should therefore be treated accordingly.