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Postischaemic interrelations between energy metabolism and functional recovery of protected canine kidneys
Author(s) -
KEHRER G.,
BLECH M.,
KALLERHOFF M.,
LANGHEINRICH M.,
BRETSCHNEIDER H.J.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00238.x
Subject(s) - renal function , nephron , kidney , chemistry , medicine , renal ischemia , energy metabolism , ischemia , concomitant , endocrinology , urology , cardiology , reperfusion injury
. Following renal ischaemia under effective protection glomerular filtration starts at a time when renal high‐energy phosphates are resynthesized. The present investigation was carried out to examine the interdependence of the two processes. Therefore, canine kidneys were protected with sodium poor and nominally Ca 2+ free buffered solutions. After different times of ischaemia and reperfusion the glomerular filtration rates (GFR) were determined and afterwards tissue specimens were excised for the determination of high‐energy phosphates. Both the GFR and the renal energy content were higher with shorter ischaemia periods or longer reperfusion. As a rule there was a correlation between GFR and ATP, both probably mainly signifying the degree of preservation of proximal nephron sites, as the interrelation between the GFR and the renal SAN (ATP+ADP+AMP) content also signifies. However, with the addition of aspartate to the protective solution it could be demonstrated that the GFR also can rise without a concomitant increase of ATP. Under certain conditions an increase of GFR can even be associated with a lowering of the renal ATP content.