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Human leucocyte rheology and tissue ischaemia
Author(s) -
CIUFFETTI G.,
MERCURI M.,
RIZZO MARIA TERESA,
LOMBARDINI RITA,
MANNARINO E.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00237.x
Subject(s) - medicine , granulocyte , monocyte , ischemia , lymphocyte , angina , immunology , cardiology , gastroenterology , myocardial infarction
. Reports suggest that white blood cells are involved in the development of tissue ischaemia. No studies on leucocyte rheology in the earliest stages of ischaemia exist. In 10 peripheral vascular disease (PVD) patients, 10 stable angina pectoris (SAP) patients and two groups of 10 matched controls leucocytes were separated by density and adherence into their granulocyte, lymphocyte and monocyte subpopulations. Blood samples were taken from the PVD group and respective controls before and after treadmill exercise (5 min 2 km ‐1 h ‐1 , 12% slope) and from the SAP patients and controls before and after cycle ergometer test (25 W every 3 min). All the subpopulations were filtered through five micron diameter pore filters. Compared to controls, calf pain in the PVD patients was associated with an increase in monocyte filterability ( P <0.01). ST depression in the SAP patients was linked to impaired granulocyte filterability ( P <0.04). Therefore leucocyte rheology appears impaired in the earliest stages of ischaemia.