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Protection of the rat gastric mucosa against aspirin injury by arachidonic acid: a dietary prostaglandin precursor fatty acid
Author(s) -
TARNAWSKI A.,
HOLLANDER D.,
STACHURA J.,
KRAUSE W. J.,
GERGELY HELLA
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00231.x
Subject(s) - arachidonic acid , aspirin , gastric mucosa , prostaglandin , fatty acid , gastric acid , chemistry , arachidonic acid metabolism , prostaglandin e , medicine , biochemistry , stomach , enzyme
. We studied aspirin‐induced injury to the gastric mucosa in control rats pretreated with a solubilizer, pluronic F‐68 (PL), and in rats pretreated with solubilized arachidonic acid (AA). Fasted male rats were pretreated intragastrically with 1 ml of either pluronic or AA and 1 h later acidified ASA (1 ml suspension of 200 mg kg ‐1 body weight) was administered intragastrically. Grossly apparent mucosal lesions developed 1 h after aspirin in pluronic‐pre‐treated rats, but were significantly reduced in AA‐pretreated rats. Histology, scanning and transmission electron microscopy demonstrated that AA pretreatment did not prevent aspirin‐induced initial damage to the surface epithelium but did significantly reduce extent of aspirin‐induced deep mucosal necrosis at 1,4 and 18 h after aspirin. Initial aspirin‐induced surface epithelial damage was rapidly restituted by two distinct types of re‐epithelialization ‐ vertical and horizontal. While the vertical type of re‐epithelialization has been reported previously as the first stage of mucosal repair following injury by various noxious agents such as concentrated ethanol, the horizontal type of re‐epithelialization, which is described for the first time in this paper, seems to be specific for the repair of aspirin‐induced gastric mucosal injury. These studies suggest that dietary factors such as essential fatty acids may play a role in gastric mucosal protection against aspirin injury.