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Platelet‐derived growth factor (PDGF) in type 1 diabetes mellitus
Author(s) -
GUILLAUSSEAU P. J.,
DUPUY E.,
BRYCKAERT M. C.,
TIMSIT J.,
CHANSON P.,
TOBELEM G.,
CAEN J. P.,
LUBETZKI J.
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00213.x
Subject(s) - platelet derived growth factor receptor , medicine , platelet , platelet derived growth factor , endocrinology , growth factor , diabetes mellitus , angiopathy , beta thromboglobulin , type 2 diabetes mellitus , stimulation , platelet factor 4 , fibroblast , chemistry , in vitro , biochemistry , receptor
. In 10 patients with type 1 diabetes mellitus, platelet‐derived growth factor (PDGF) was assessed using an in vitro assay based on the stimulation of DNA synthesis in the 3T3 mouse fibroblast cell line. β‐Thromboglobulin (β‐TG) was used as an index for platelet α‐granules content. Platelet β‐TG content and PDGF were markedly decreased in diabetic patients while plasma β‐TG was increased as compared with control subjects. In diabetic patients, a significant negative correlation was found between plasma β‐TG level and β‐TG total platelet content, associated with a significant positive correlation between platelet β‐TG content and PDGF. These results suggest that PDGF release might be increased in diabetic subjects. This may account in part for the cell proliferation observed in diabetic angiopathy.