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Effect of a soluble bacterial carbohydrate fraction on the viscosity of intestinal contents in healthy subjects and patients with Crohn's disease
Author(s) -
HAZENBERG M. P.,
PENNOCKSCHRÖDER A. M.,
WENSINCK F.,
MERWE J. P. VAN DE
Publication year - 1989
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1989.tb00196.x
Subject(s) - muramic acid , fraction (chemistry) , crohn's disease , feces , viscosity , carbohydrate , chemistry , size exclusion chromatography , gastroenterology , glycoprotein , disease , microbiology and biotechnology , food science , medicine , biochemistry , chromatography , biology , materials science , enzyme , peptidoglycan , composite material
. Supernatants of faecal suspensions from patients with Crohn's disease (CD) showed much lower viscosity than those from healthy subjects. Material responsible for the viscosity could be precipitated with ethanol. Gel filtration indicated that the viscosity was not due to the glycoprotein fraction but to a fraction with higher molecular weight and relatively high contents of muramic acid suggesting a bacterial origin. The concentration and viscosity of this fraction are less in faeces from patients with CD than in that of healthy subjects.