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Cholecystokinin is a physiological hormonal mediator of fat‐induced inhibition of gastric emptying in man
Author(s) -
KLEIBEUKER J. H.,
BEEKHUIS H.,
JANSEN J. B. M. J.,
PIERS D. A.,
LAMERS C. B. H. W.
Publication year - 1988
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1988.tb02409.x
Subject(s) - cholecystokinin , gastric emptying , medicine , endocrinology , saline , radioimmunoassay , gastrointestinal hormone , meal , chemistry , hormone , peptide hormone , stomach , receptor
. The effect of cholecystokinin‐33 on gastric emptying was studied in eight healthy men. The test meal was a firm custard pudding, labelled with 99m Tc‐Chelex‐100 particles. Gastric emptying rate was measured, using a dual‐headed gamma camera, and was expressed as the half time of the emptying curve. Plasma cholecystokinin concentrations were determined by radioimmunoassay. Subjects were studied three times: (i) during infusion of saline; during cholecystokinin infusion, (ii) 0·375 IDU kg −1 h −1 and (iii) 0·75 IDU kg −1 h −1 . Furthermore, plasma cholecystokinin was determined after a regular meal. During saline, plasma cholecystokinin increased minimally. After the regular meal it increased from 1·6 to 6·5 pmol l −1 at 30 min, decreasing to 5·3 pmol l −1 at 60 min. During the lower and higher doses of cholecystokinin it increased from 10 and 1·4 to 4·5 and 7·3 pmol l −1 , respectively. The lower and higher doses significantly ( P < 0·05) increased half emptying time, from 45 ± 8 to 86 ± 17 and 198 ± 50 min, respectively. Cholecystokinin is most likely a physiological hormonal mediator of fat‐induced inhibition of gastric emptying.