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The effect of long‐term fibre and starch intake by man on faecal bile acid excretion
Author(s) -
GHOOS Y.,
RUTGEERTS P.,
VANTRAPPEN G.,
HIELE M.,
SCHURMANS P.
Publication year - 1988
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1988.tb02402.x
Subject(s) - bile acid , excretion , medicine , feces , starch , cholesterol , triglyceride , chemistry , dry weight , zoology , endocrinology , food science , biology , microbiology and biotechnology , agronomy
. Parameters of bile acid metabolism were studied in two populations with different dietary fibre and starch intake over a period of at least 5 years. Subjects with a high fibre and starch intake have significant increases in faecal wet weight (288·5 g day −1 vs. 136·1), faecal dry weight (39·3 g day −1 vs. 20·2), faecal bile acid excretion (3930 mg day −1 vs. 115·4) and faecal bile acid:faecal dry weight ratio (13·6 vs. 5·8). There was no difference in bowel transit time measured with 3 H‐PEG 4000 as marker of the liquid phase. The cumulative 14 CO 2 excretion during the bile acid breath test was higher in the high‐fibre group, compared with the low‐fibre group (4·6% dose cumulative at 8 h vs. 2·5%). Serum triglyceride and cholesterol levels were comparable in both groups. It is suggested that increased faecal weight and bile acid secretion is due to the synergic effect of high fibre and starch intake upon colonic bacterial proliferation.