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Role of atrial natriuretic factor, cyclic GMP and the renin–aldosterone system in acute volume regulation of healthy human subjects
Author(s) -
GERBES A. L.,
ARENDT R. M.,
GERZER R.,
SCHNIZER W.,
JÜNGST D.,
PAUMGARTNER G.,
WERNZE H.
Publication year - 1988
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1988.tb01035.x
Subject(s) - medicine , endocrinology , natriuresis , aldosterone , plasma renin activity , chemistry , cyclic guanosine monophosphate , diuresis , renin–angiotensin system , stimulation , atrial natriuretic peptide , excretion , kidney , blood pressure , nitric oxide
The role of the atrial natriuretic factor (ANF), its second messenger cyclic guanosine monophosphate (cGMP), and the counteracting reninaldosterone system in acute volume regulation was investigated in 25 healthy human subjects. Central volume stimulation by 1‐h head‐out water immersion (WI) into a thermoneutral water‐bath increased plasma levels of ANF (mean ± SEM) from 6·0 ± 0·6 to 13·6 ± 2·6 fmol ml ‐1 . This was paralleled by a rise of plasma cGMP levels from 1·9 ± 0·2 to 2·8 ± 0·4 pmol ml ‐1 , and an increase of urinary cGMP excretion from 340 ± 64 to 692 ± 103 pmol min ‐1 . Water immersion reduced plasma aldosterone concentration (PAC) from 13·0 ± 1·7 to 6·5 ± 0·8 ng 100 ml ‐1 and plasma renin activity (PRA) from 5·3 ± 0·9 to 2·4 ± 0·3 ng AI ml ‐1 h ‐1 . Volume stimulation markedly increased diuresis and natriuresis. Whereas the plasma cGMP increase correlated with plasma ANF stimulation, neither ANF nor PRA or PAC correlated with basal or stimulated renal parameters. Water immersioninduced changes in natriuresis and urinary cGMP excretion were correlated. These data suggest a role of ANF and cGMP in acute volume regulation of healthy human subjects.