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Radionucleide tests for the assessment of intestinal permeability
Author(s) -
BEHRENS R. H.,
SZAZ K. F.,
NORTHROP C.,
ELIA M.,
NEALE G.
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb02387.x
Subject(s) - coeliac disease , excretion , intestinal permeability , mannitol , medicine , gastroenterology , lactulose , urine , gluten free , endocrinology , disease , chemistry , biochemistry
. 14 C labelled‐D‐mannitol and aquo (ethylenediaminetriacetoacetic acid) 51 chromium (III) ( 51 Cr EDTA) have been evaluated as markers of intestinal permeability in twenty‐four healthy control subjects, sixteen patients with recently diagnosed coeliac disease and twenty subjects with coeliac disease in remission on a gluten‐free diet. The percentage excretion of 14 C mannitol in urine collected for 6 h was significantly less in patients with coeliac disease (mean 6·7%) than controls (mean 13·5%). Conversely the excretion of 51 Cr EDTA was significantly greater in patients with coeliac disease (mean 1·23%) compared with controls (mean 0·28%). The mean ratio of the percentage excretion of 51 Cr to the percentage excretion of 14 C was 0·29 in patients with untreated coeliac disease compared with 0023 for healthy control subjects ( P < 0001). Patients with untreated coeliac disease were clearly separated from control subjects by use of the 51 Cr EDTA: 14 C mannitol ratio but not by the excretion of independent markers.