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Time‐course of alterations of high density lipoproteins (HDL) during thyroxine administration to hypothyroid women
Author(s) -
VERDUGO CECILIA,
PERROT L.,
PONSIN G.,
VALENTIN CATHERINE,
BERTHEZENE FRANÇOIS
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb02193.x
Subject(s) - medicine , endocrinology , cholesterol , apolipoprotein b , high density lipoprotein , chemistry , thyroid , hormone , metabolism
. Serum HDL cholesterol, apolipoproteins AI and All and post heparin lipolytic activities (PHLA) have been measured in a group of fourteen hypothyroid women without ovarian oestrogen secretion before and during a 2‐month thyroxine treatment. The more rapid and consistent observed event was a decrease in apo Al levels (164 ± 5 vs. 149±5 mg dl ‐1 , mean ± SEM, P <0·05) correlated ( r =0·79, P <0·05) to a slight increment of PHLA. A slight decrease in apo All concentration was seen only after 5 days (25 ± 2 vs. 22 ± 2 mg dl ‐1 , P < 0·05) and in HDL cholesterol only after 60 days (1·3±0·6 vs. 1·1±0·5 mmol l ‐1 , P <0·05). Apo AI, HDL2 and HDL3 cholesterol were measured in another group of seven hypothyroid post‐menopausal women before and after a 2‐month thyroxine treatment. We observed a decrease in HDL2 cholesterol (1·69 ± 0·20 vs. 1·17±0·09 mmol l ‐1 , P <0·02) with no changes in HDL3 cholesterol (0·88±0·09 vs. 0·99±0·06 mmol l ‐1 , NS). The decrease in HDL2 cholesterol correlated ( r = 0·72, P = 0·05) with that for apo AI. The differential influence of thyroxine (T4) administration on the major HDL components might reflect changes in HDL composition due to the multiple effects of thyroid hormones on lipid metabolism. It can be hypothesized that the decrease in apo AI and HDL2 cholesterol concentrations are due, at least in part, to the increase in hepatic lipase activity.