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Type 1 (insulin‐dependent) versus Type 2 (non‐insulin‐dependent) diabetes mellitus: characterization of serum lipoprotein alterations
Author(s) -
WEISWEILER P.,
SCHWANDT P.
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb01231.x
Subject(s) - medicine , endocrinology , insulin , diabetes mellitus , type 2 diabetes mellitus , lipoprotein , type 2 diabetes , lipoprotein(a) , cholesterol
. Serum lipoprotein lipids and apolipoproteins A‐I, B, and E were investigated in Type 1 (insulin‐dependent) diabetics, Type 2 (non‐insulin‐dependent) diabetics, and two control groups, twenty subjects each. Lipoproteins were separated and analysed by common methods, apolipoproteins were measured by endpoint immunonephelometry. Compared with controls, Type 2 diabetics had increased serum apolipo‐protein E levels (0·116 pL 0·020 vs. 0·079 pL 0·014 g l ‐1 , P < 0·01) together with an increased content of cholesteryl ester‐enriched very low‐density lipoproteins. Furthermore, Type 2 diabetics had higher apolipoprotein B concentrations (1·06 pL 0·21 vs. 0·85 pL 0·21 g l ‐1 P < 0·01), but lower high‐density lipoprotein cholesterol concentrations than the controls. Conversely, Type 1 diabetics had elevated serum apolipoprotein A‐I values vs. controls and Type 2 diabetics (1·70 pL 0·33 vs. 1·49 pL 0·22 and 1·43 pL 0·21 g l ‐1 , P < 0·01). It is concluded that Type 2 diabetics, like other groups at risk for atherosclerotic diseases, are characterized by an increased concentration of partly catabolized very low‐density lipoproteins. Sufficiently insulinized Type 1 diabetics have, on the other hand, an increased number of high‐density lipoprotein particles.