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Haematological and hormonal responses to dynamic exercise in patients with chronic airway obstruction
Author(s) -
GIMENEZ M.,
MOHANKUMAR T.,
HUMBERT J.C.,
TALANCE NICOLE DE,
TEBOUL M.,
PONZy J. L.,
POLU J. M.
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb01229.x
Subject(s) - platelet , medicine , white blood cell , hormone , endocrinology , airway obstruction , rest (music) , airway , surgery
. The influence of exercise on hormonal and total white blood cells (WBC), lymphopcytes (L). Granulocytes (GR), and platelet (P) count responses was studied in: twenty‐five patients with chronic airway obstruction (CAO, 47 pL 1·8 years, ±x pL SEM) and thirteen normal subjects (N, 36 pL 2·6 years). They performed a submaximal (40 W) and a maximal exercise (±VO 2 max). Arterial blood samples were taken at rest, 40 W, and ±VO 2 max. [H + ], PaCO 2 , PaO 2 haematocrit (Hct), [Hb], P, total platelet volume (TPV), WBC, GR, L, and total red blood cells (RBC) were measured. At rest, WBC, GR, P and TPV were higher in CAO patients, whilst PaO 2 and cortisol were lower. At 40 W, when compared to values obtained at rest, WBC, GR, L, P and TPV were increased in both groups; WBC, GR, P and TPV were higher in CAO patients. ±VO 2 max of CAO patients represented 54% of that of controls. At ±VO 2 max, Hct, [Hb] and RBC were approximately 10% higher than at rest in both groups, whilst changes were more significant in normals for WBC (CAO = 55%, N = 76%), lymphocytes (CAO = 83%, N = 105%), GR, (CAO = 37%; N = 51%), platelets (CAO = 23%, N = 29%), TPV (CAO = 25·4%, N = 35%), [H + ] (CAO = 43%, N = 38%) and ACTH (CAO = 82%, N = 139%). PaO 2 and cortisol did not differ between groups. PaCO 2 and platelets however, were higher in the CAO group. Ambient temperature, age and degree of bronchial obstruction at rest, as well as haemoconcentration, PaO 2 , acidosis and cortisol during exercise do not seem to be responsible for the higher WBC and platelet values observed in patients.