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Insulin sensitivity and beta‐cell function assessed by C‐peptide in young adults with cystic fibrosis
Author(s) -
DAVIS T. M. E.,
BATTEN J. C.,
RUDENSKI A. S.,
TURNER R. C.
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb01219.x
Subject(s) - medicine , endocrinology , cystic fibrosis , impaired glucose tolerance , insulin , insulin sensitivity , beta cell , c peptide , diabetes mellitus , beta (programming language) , insulin response , glucose tolerance test , insulin resistance , cystic fibrosis related diabetes , plasma glucose , islet , computer science , programming language
. Eight patients with cystic fibrosis (CF) aged 18–34 who had normal random plasma glucose levels were studied with a continuous infusion of glucose with model assessment (CIGMA) and plasma C‐peptide to assess beta‐cell function, and plasma insulin to assess insulin sensitivity. Two had impaired glucose tolerance, two had impaired beta‐cell function and all had normal insulin sensitivity. The results of previous studies suggesting that glucose intolerance is common in CF may reflect the inability of an impaired liver to handle a large oral glucose load. The few CF patients who become diabetic may be those who have a preexisting diabetic trait.