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Alcohol impairs age‐dependent adaptation of human lymphocyte beta‐adrenergic receptors
Author(s) -
PADOVANI A.,
GOVONI S.,
BATTAINI F.,
MAGI MARIA SANDRA,
CIVELLI L.,
MAURI A.,
PICOTTI G. B.,
GALVA MARIA DONATA,
TRABUCCHI M.
Publication year - 1987
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1987.tb01150.x
Subject(s) - iodocyanopindolol , medicine , endocrinology , receptor , norepinephrine , adrenergic receptor , lymphocyte , beta (programming language) , chemistry , radioligand , adrenergic , biology , agonist , intrinsic activity , dopamine , computer science , programming language
. Lymphocyte beta‐adrenergic receptor function and norepinephrine (NE) plasma concentration have been compared in normal subjects and in ethanoladdicted patients of different ages. Direct measurement of the density and properties of beta‐adrenoceptors in membrane fractions was performed using the radioligand 125 I‐Iodocyanopindolol (ICYP). In normal subjects beta‐receptor density decreased and norepinephrine plasma concentration increased with age. There was a statistically significant negative correlation between plasma norepinephrine and beta‐receptor number. In ethanol‐addicted patients the agerelated modification in beta‐receptor number and the correlation between plasma norepinephrine and beta‐receptor density were lost, in spite of the fact that the increase of NE plasma concentration was still present. The ethanol‐induced effects in lymphocyte beta‐receptor may have consequences on immunological function and may be qualitatively similar to alterations in other tissues not routinely accessible in humans.