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High content of dietary linoleic acid does not reduce platelet reactivity in patients with hyperlipoproteinaemia
Author(s) -
BOBERG M.,
GUSTAFSSON I.B.,
VESSBY B.
Publication year - 1986
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1986.tb01303.x
Subject(s) - linoleic acid , arachidonic acid , chemistry , platelet , medicine , endocrinology , metabolite , fatty acid , lipoprotein , cholesterol , low density lipoprotein , high density lipoprotein , biochemistry , food science , enzyme , biology
. Seventeen patients with hypertriglyceridaemia were given a lipid‐lowering diet with a high P/S‐ratio 2·1 during a 3‐week period. The very low density lipoprotein triglycerides decreased by 43%, low density lipoprotein cholesterol by 19% and high density lipoprotein cholesterol by 12%. There was a marked increase of linoleic acid (18:2 n ‐6) in all plasma lipid esters with a concomitant decrease of the saturated and monounsaturated fatty acids. There was a slight increase of the linoleic acid metabolites 18:3 n ‐6, 20:3 n ‐6 and 20:4 n ‐6 in serum triglycerides whereas the fatty acids of the n ‐3 series decreased in all plasma lipid esters. In the platelets a similar pattern was found with an increase of linoleic acid and its metabolite 22:4 n ‐6 and a decrease of 18:1 n ‐9 as well as of the n ‐3 fatty acids. No significant differences in platelet reactivity was found. However, in a few patients there was an increased platelet aggregation after the diet period. Our results suggest that this diet based on a very high content of linoleic acid may not affect platelet reactivity in a beneficial way. The reason may be an increased turnover of arachidonic acid in the platelets or an imbalance between the n ‐6 and n ‐3 series of fatty acids.