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Dispositions of di‐ and mono‐(2‐ethylhexyl) phthalate in newborn infants subjected to exchange transfusions
Author(s) -
SJÖBERG P.,
BONDESSON U.,
SEDIN G.,
GUSTAFSSON J.
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00297.x
Subject(s) - phthalate , metabolite , limiting , exchange transfusion , chemistry , plasticizer , body weight , plasma concentration , half life , endocrinology , medicine , pharmacokinetics , biochemistry , organic chemistry , mechanical engineering , engineering
. The dispositions of the plasticizer di‐(2‐ethylhexyl) phthalate (DEHP) and its primary metabolite mono‐(2‐ethylhexyl) phthalate (MEHP) were studied in newborn infants subjected to exchange transfusions. During a single exchange transfusion the amounts of DEHP and MEHP infused ranged from 0±8‐3±3 and 0±05‐0±20 mg kg ‐1 body weight, respectively. There were indications that about 30% of the infused DEHP originated from parts of the transfusion set other than the blood bag. Approximately 30% of the infused amount of DEHP was withdrawn during the course of each transfusion. Immediately after the transfusions the plasma levels of DEHP ranged between 5±8 and 19±6 μg ml ‐1 , and subsequently they declined rapidly. This decline, probably reflecting distribution of DEHP within the body, was followed by a slower elimination phase. The half‐life of this phase was approximately 10 h. The maximal plasma levels of MEHP were about 5 μg ml ‐1 . In one pre‐term infant the elimination of MEHP was slower than its formation, whereas in one full‐term newborn the formation appeared to be rate‐limiting for the elimination.