Premium
Reduced strength of skin in osteogenesis imperfecta
Author(s) -
OXLUND HANS,
PEDERSEN ULRIK,
DANIELSEN CARL CHRISTIAN,
OXLUND INGER,
ELBRØOND OLE
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00293.x
Subject(s) - osteogenesis imperfecta , type i collagen , ultimate tensile strength , medicine , endocrinology , dentistry , pathology , materials science , composite material
. The biochemical properties and ratio collagen type I/type III of skin biopsies from nine patients with osteogenesis imperfecta and nine age‐ and sex‐matched controls were studied. Four of six patients with osteogenesis imperfecta Sillence type I had pronounced reductions in skin tensile strength, decreased ratios of collagen type I/type III, primarily accomplished by reduced amounts of collagen type I, moderate or no disability. The three patients with osteogenesis imperfecta Sillence type III had severe skeletal deformities, but normal skin tensile strength, and ratios of collagen type I/type III within the normal range. These observations may be explained as resulting from various structural defects in the type I collagen of patients with osteogenesis imperfecta.