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Total and unbound Cortisol‐, progesterone‐, oestrone‐ and transcortin‐binding activities in sera from patients with myocardial infarction: evidence for differential responses of good and bad prognostic cases
Author(s) -
ZOUAGHI HASSEN,
SAVU LIA,
GUEROT CLAUDE,
GRYMAN RAYMOND,
COULON ALINE,
NUNEZ EMMANUEL A.
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00286.x
Subject(s) - transcortin , medicine , myocardial infarction , endocrinology , hydrocortisone , cardiology , globulin
. Day‐of‐admission sera from myocardial infarction patients (MI) and patients with cardiopathies other than MI (non‐MI) were analysed for total and unbound Cortisol (F), progesterone (P 4 ), oestrone (E 1 ), and corticosteroid binding activities (CBG). The MI who survived ( n = 28) showed high increases of F, P 4 and E 1 compared to healthy controls. By contrast, the MI who died within 10 days of admission ( n = 6) had unchanged F and less increased P 4 and E 1 than survivors. The non‐MI ( n = 6) had higher F and E 1 than controls but normal P 4 . The unbound steroids were increased in all patients: however, the MI who died showed much smaller rises than survivors ( P < 0±001 for unbound F and E 1 increases in survivors vs. deceased). The CBG activity was in all MI lower than in normals ( P <0±001) but unchanged in non‐MI. These results are discussed in terms of the potential significance of unbound plasma steroids as predictors of MI severity.