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Relationship between turnover rate and oxidation rate of alanine in the post‐absorptive state and during parenteral nutrition before and after surgery
Author(s) -
SAUERWEIN H. P.,
MICHELS R. P. J.,
CEJKA V.
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00181.x
Subject(s) - alanine , parenteral nutrition , turnover , chemistry , protein turnover , alanine aminotransferase , metabolism , medicine , surgery , biochemistry , protein biosynthesis , amino acid , management , economics
. The influence of total parenteral nutrition and stomach resection on alanine turnover rate and alanine oxidation rate was measured in ten patients after single injection of U‐ 14 C‐alanine. Sequential studies were done in three patients. During parenteral nutrition alanine turnover was significantly higher than in the post‐abortive state (14·75 ± 2·56 μmol kg ‐1 min ‐1 and 8·48 ± 1·88 μmol kg ‐1 min ‐1 , respectively; P <0·01, mean ± s.d.)‐ Surgery had no additional significant influence on alanine turnover. In the post‐absorptive state 4·71 ± 0·71 /μmol kg ‐1 min ‐1 was oxidized, during parenteral feeding before surgery 7·93 ± 1·93 μmol kg ‐1 min ‐1 ( P <0·01 v. post‐absorptive state), and during parenteral feeding after surgery 7·67 ± 1·67 μmol kg ‐1 min ‐1 . The percentages of alanine turnover used for oxidation in the post‐absorptive state and during parenteral feeding before and after surgery were 57 ± 11%, 54 ± 7% and 45 ±11%, respectively (no significant differences). It is concluded that the degree of alanine oxidation seems to be directed by the degree of alanine turnover. A discussion about differences in alanine oxidation under different circumstances must therefore include a discussion about changes in alanine turnover.