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Active and acid‐activable inactive rennin during inhibition by indomethacin of prostaglandin synthesis in sodium‐replete man
Author(s) -
LIJNEN P.,
STAESSEN J.,
FAGARD R.,
GROESENEKEN D.,
M'BUYAMBAKABANGU J. R.,
GRAUWELS R.,
AMERY A.
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00158.x
Subject(s) - chemistry , endocrinology , prostaglandins f , medicine , prostaglandin , renin–angiotensin system , plasma renin activity , prostaglandin antagonist , prostaglandin e2 , stimulation , prostaglandin e , alpha (finance) , placebo , sodium , blood pressure , surgery , construct validity , alternative medicine , organic chemistry , pathology , patient satisfaction
. The effect of inhibition of prostaglandin synthesis by indomethacin on active renin and on acid‐activable inactive renin was studied in nine healthy, sodium‐replete men, both at rest and exercise. These volunteers were investigated after pretreatment with placebo or indomethacin, 150 mg daily for 3 days. Indomethacin induced a decrease in active ( P = 0·004), total ( P < 0·001) and inactive ( P = 0·02) renin at rest recumbent and at rest, sitting. Inhibition of prostaglandins with indomethacin reduced ( P < 0·001) active and total renin at each level of work load but not ( P = 0·32) inactive renin. However the exercise‐induced stimulation ( P < 0·05) of active and of total renin still occur during indomethacin. Indomethacin reduced ( P < 0·001) at rest, sitting and at maximal exercise the plasma concentrations of immunoreactive prostaglandins E 2 , prostaglandin F 2α , and 13,14‐dihydro‐15‐keto‐prostaglandin F α ; the urinary excretion of immunoreactive prostaglandin E 2 and F 2α were also reduced.