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Stimulation of peritoneal synthesis of vasoactive prostaglandins during peritonitis in patients on continuous ambulatory peritoneal dialysis
Author(s) -
STEINHAUER H. B.,
GÜNTER B.,
SCHOLLMEYER P.
Publication year - 1985
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1985.tb00135.x
Subject(s) - peritoneal dialysis , peritonitis , continuous ambulatory peritoneal dialysis , medicine , endocrinology , peritoneal fluid
. The peritoneal generation of arachidonic acid metabolites was studied in eight patients with end‐stage renal disease undergoing continuous ambulatory peritoneal dialysis (CAPD) during infection‐free periods and during bacterial peritonitis. The prostacyclin metabolite 6‐keto‐PGF 1α was found to be the major prostanoid generated by human peritoneal mesothelium (1090 ng(6h) ‐1 , SEM 86, n = 8) followed by lesser amounts of PGE 2 (142 ng (6 h) ‐1 , SEM 26, n = 8), PGF 2α (162ng(6h) ‐1 , SEM 27, n = 8) and TXB 2 (59 ng (6 h) ‐1 , SEM 5, n = 8). During peritonitis a significant increase of all prostaglandins and TXB 2 occurred ( P < 0·001). The ratio of the vasodilating prostaglandins and their metabolites (PGE 2 and 6‐keto‐PGF 1α ) to the vasoconstrictors and their metabolites (PGF 2α and TXB 2 ) increased from 6·6 to 10·5 during peritoneal inflammation. Augmented peritoneal clearances of creatinin and urea and increased losses of proteins during peritonitis as well as the enhanced peritoneal generation of prostanoids were reduced to basal values by adequated antibiotic therapy. The present results suggest that the increased peritoneal blood flow during peritonitis, probably responsible for the observed changes of peritoneal transport properties, may be induced by a change in the ratio of vasoactive prostaglandins generated by peritoneal mesothelial cells.