Premium
Effects of cyclooxygenase inhibitors, prostaglandins F 2α and I 2 , on isolated coeliac and basilar arteries of alloxan‐diabetic dogs
Author(s) -
KOLTAI M. Z.,
HADHÁZY P.,
MALOMVÖLGYI B.,
WAGNER M.,
POGÁTSA G.
Publication year - 1984
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1984.tb02101.x
Subject(s) - medicine , endocrinology , basilar artery , cyclooxygenase , prostacyclin , alloxan , diabetes mellitus , vasodilation , chemistry , enzyme , biochemistry
. The effects of prostaglandin synthetase inhibitors PGF 2α and PGI 2 on the tone of isolated basilar and coeliac arteries were studied in healthy and alloxan‐diabetic dogs. PGF 2α (1 μmol l ‐1 ) produced a significantly higher tone in diabetic basilar arteries (1·15 ± 0·16 mN) than in normal cerebral vessels (0·7 + 0·10 mN). By contrast, the contractile responses of normal and diabetic coeliac arteries to PGF 2α did not differ. The cyclooxygenase inhibitors indomethacin (3 μmol l ‐1 ) and suprofen (0·58 μmol l ‐1 ) potentiated the PGF 2α ‐evoked contractions in all of the vessels studied. The percent potentiation was greater (50–60%) in the basilar arteries from alloxan‐treated dogs than in normal basilar vessels (22–30%). There was not such a difference between diabetic and normal coeliac arteries. Prostacyclin produced a concentration‐related relaxation in the presence of indomethacin or indomethacin + PGF 2α . The relaxant potencies of PGI 2 were similar in the vessels from metabolically healthy and diabetic dogs. The IC 50 values for PGI 2 were 11·6 ± 1·3 and 11·8 ± 1·8 nmol l ‐1 in normal and diabetic basilar arteries, respectively; they were 25·4 ± 3·2 and 26·2 ± 3·9 nmol l ‐1 in control and alloxan‐treated coeliac vessels. These results indicate that normal and diabetic vessels may have differential reactivity to cyclooxygenase inhibitors, this difference being dependent on the vascular region.