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Iodine‐induced thyrotoxicosis: analysis of eighty‐five consecutive cases
Author(s) -
LEGER AUBÈNE F.,
MASSIN JEAN P.,
LAURENT MARIE F.,
VINCENS MONIQUE,
AURIOL MICHÈLE,
HELAL OURKIA B.,
CHOMETTE GUY,
SAVOIE JEAN C.
Publication year - 1984
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1984.tb01212.x
Subject(s) - iodine , thyroid , medicine , endocrinology , hormone , prednisone , thyroglobulin , chemistry , organic chemistry
. Iodine‐induced thyrotoxicosis was documented in eighty‐five cases. Eighty per cent occur in apparently normal thyroid glands; 60% among them occur in males. Amiodarone accounted for 50% of iodine‐induced thyrotoxicosis. Mean thyroid hormone levels at diagnosis were: FT 1 : 21·7 (normal mean: 7·5, arbitrary units); T 3 : 4·53 nmol l ‐1 (normal: 2·30 nmol l ‐1 ). Mean 131 I ‐ 24‐h uptake was 3·5% (normal range in France 25–45%) and was activated by exogenous TSH (mean 27%). The spontaneous cure in non‐treated cases was observed within an average 6 months. A phase of biological hypothyroidism (mean FT 1 : 3·7, T 3 : 1·23 nmol l ‐1 , TSH: 9·6 μU ml ‐1 (normal TSH range: 1–7 μU ml ‐1 )) preceded the return to euthyroidism. Intrathyroid iodine content measured by X‐ray fluorescence was high, then fell gradually. Thyroid tissue study showed a large quantity of intrathyroid iodine and the overiodination of thyroglobulin. Histological and electron microscopic studies are reported. Prednisone and in some cases propylthiouracile were found to be effective.