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Effect of dipyrone, acetylsalicylic acid and acetaminophen on human neutrophil chemotaxis
Author(s) -
MATZNER YAACOV,
DREXLER RUTH,
LEVY MICHA
Publication year - 1984
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1984.tb01210.x
Subject(s) - acetaminophen , chemotaxis , pharmacology , aspirin , chemistry , medicine , biochemistry , receptor
. Dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐formylaminoantipyrine (FAA) as well as acetylsalicylic acid inhibited neutrophil migration toward zymosan‐activated serum. Inhibition was maximal (76·8 pL 19·0; 79·2 pL 12·5 and 80·0 pL 4·4%, respectively, P < 0·003) when suboptimal concentrations (0·3%) of the chemoattractant were used and could be demonstrated with drug concentrations comparable with plasma concentrations obtained in clinical use. Acetaminophen and other dipyrone metabolites 4‐aminoantipyrine (AA) and 4‐acetylaminoantipyrine (AAA) lacked chemotactic inhibitory potential. Only MAA and FAA inhibited mildly neutrophil random migration (18·1 pL 7·8 and 11·2 pL 3·4%, respectively). We suggest that blocking neutrophil movement plays a role in the anti‐inflammatory activity of dipyrone and acetylsalicylic acid, but their mechanism of inhibition remains obscure.