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Direct and indirect measurement of urinary kallikrein excretion in patients with essential hypertension and normotensives: relation to age and plasma renin and aldosterone levels
Author(s) -
KOOLEN M. I.,
DAHA M. R.,
FRÖLICH M.,
ES L. A. VAN,
BRUMMELEN P. VAN
Publication year - 1984
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1984.tb01118.x
Subject(s) - aldosterone , medicine , excretion , endocrinology , plasma renin activity , renin–angiotensin system , radioimmunoassay , basal (medicine) , chemistry , essential hypertension , urinary system , blood pressure , insulin
. The relevance of age and activity of the renin‐angiotensin‐aldosterone system to the excretion of urinary kallikrein (Ukal) was studied in twenty‐five patients with essential hypertension and forty normotensive controls. The age range for both study groups was 20–60 years. Ukal was measured by radioimmunoassay and by an amidolytic assay. Results of both assays correlated closely ( r = 0·93, n = 65, P < 0·001). For all hypertensives Ukal excretion was not significantly different from that of controls. However, older hypertensives (> 40 years, n = 13) had a significantly lower Ukal excretion than normotensives of the same age ( n = 20) (radioimmunoassay 67·2 (SEM 7·2) v. 105·1 (SEM 8·4) μ g (24 h) ‐1 ; and amidolytic method 0·84 (SEM 0·10) v. 1·13 (SEM 0·08) U (24 h) ‐1 ). No correlation was found between Ukal excretion and plasma renin or aldosterone. In fact, the aldosterone level was highest in older hypertensives. In conclusion, the lower Ukal excretion in hypertensives over 40 is likely to be secondary to the long‐standing high blood pressure. Under basal conditions, Ukal excretion seems little influenced by the activity of the renin‐angiotensin‐aldosterone system.