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Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)
Author(s) -
VERGANI CARLO G.,
PLANCHER ANGELO C.,
ZUIN MASSIMO,
CATTANEO MARCO,
TRAMALONI CASIMIRO,
MACCARI SERGIO,
ROMA PAOLA,
CATAPANO ALBERICO L.
Publication year - 1984
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1984.tb00703.x
Subject(s) - tangier disease , cholesterol , medicine , platelet , endocrinology , high density lipoprotein , coagulation , chemistry , biochemistry , transporter , abca1 , gene
. A 62‐year‐old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of bilary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper‐responsive to aggregating agents and produced an increased amount of thromboxane B 2 . A platelet storage pool deficiency was also found.