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Diabetes mellitus, glucose tolerance and insulin response to glucose in patients with primary hyperparathyroidism before and after parathyroidectomy
Author(s) -
LJUNGHALL S.,
PALMÉR M.,
ÅKERSTRÖM G.,
WIDE L.
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00116.x
Subject(s) - medicine , primary hyperparathyroidism , diabetes mellitus , endocrinology , parathyroidectomy , parathyroid hormone , impaired glucose tolerance , insulin , population , hyperparathyroidism , pathological , calcium , gastroenterology , insulin resistance , environmental health
. In a retrospectively analyzed series of 441 patients operated for primary hyperparathyroidism (HPT), the prevalence of diabetes mellitus was 8.2%, which was three times higher than in the unselected age‐matched population. Following parathyroid surgery, the need for antidiabetic treatment was unchanged. The insulin response to an intravenous glucose load was enhanced preoperatively [95 mU/l ± 41 (SD)] in twenty‐six prospectively studied patients compared to postoperative (65 ± 41 mU/l) investigations ( P < 0.01). This response was inversely correlated ( r = 2, P < 0.01) to the serum phosphate concentrations but not related to calcium or parathyroid hormone levels. Postoperatively, most HPT patients experienced a deterioration of their glucose tolerance (t for i.v. glucose 54 ± 12 and 64 ± 21 min, respectively, P < 0.05), and one‐third of them had pathological values at follow‐up. Despite this, neither the fasting blood glucose levels nor the values for haemoglobin A 1c were significantly affected.