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Fibrinolytic activity of the gastric mucosa in Ménétrièr's disease
Author(s) -
WIJNGAARDS G.,
JESPERSEN J.
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00111.x
Subject(s) - plasminogen activator , gastric mucosa , medicine , chemistry , cimetidine , gastroenterology , endocrinology , stomach
. Biopsies of the gastric mucosa were collected from two patients with Menetrier's disease before, during, and after treatment with cimetidine and studied for fibrinolytic activity. The fibrinolytic activity in the homogenates or in the potassium thiocyanate soluble fractions increased markedly during the treatment. Immunological characterization of the activity indicated that its major component was an endothelium‐derived type of plasminogen activator, and that the increase in activity was caused solely by an increase in the concentration of this component. This suggests an increase in the vascularity of the mucosal layers during treatment thus reflecting a repair process.