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Abnormal Na + K + cotransport function in a group of patients with essential hypertension
Author(s) -
GARAY R. P.,
NAZARET C.,
HANNAERT P.,
PRICE M.
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00106.x
Subject(s) - cotransporter , medicine , essential hypertension , endocrinology , chemistry , population , stimulation , sodium , blood pressure , environmental health , organic chemistry
. In 50 normotensive controls, the increase in erythrocyte Na + concentration up to 12.4 ± 2.0 mmol/l cells (mean ± SD) ensures half‐maximal stimulation of outward Na + K + cotransport fluxes. Forty‐six out of sixty‐five patients with essential hypertension required more than 16 mmol/l cells of internal Na + concentration to obtain a similar effect, strongly suggesting an abnormal cotransport function. Seven out of fourteen hypertensive patients with normal Na, K cotransport function showed Na + Li + countertransport fluxes higher than the normal upper limit of 220 μmol (1 cells h) ‐1 . Conversely, counter‐transport fluxes were normal in fourteen hypertensives with abnormal cotransport function. The above results indicate that the total population of patients with essential hypertension is heterogenous and includes one subgroup of subjects with abnormal Na + K + cotransport function, and another with increased Na + Li + countertransport fluxes.