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Effects of retrograde luminal perfusion of the canine jejunum on intestinal absorption and myoelectrical activity
Author(s) -
MITCHELL ANDREW,
COLLIN JACK,
DENTON TERENCE G.
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00096.x
Subject(s) - perfusion , jejunum , absorption (acoustics) , medicine , gastroenterology , chemistry , transit time , materials science , transport engineering , engineering , composite material
. The effects of retrograde luminal perfusion of a 75 cm jejunal segment on absorption, transit time and myoelectrical activity were studied in four dogs. Retrograde perfusion increased jejunal absorption of water (0.016–0.021 ml cm intestinal length ‐1 min ‐1 ; P < 0.001) together with sodium (1.15‐1.82 μmol cm ‐1 min ‐1 ; P < 0.001) and glucose (1.98‐2.27 μmol cm ‐1 min ‐1 ; P < 0.01). Mean jejunal transit time was prolonged (9.2–13.9 min; P < 0.001) and jejunal spike activity was reduced compared with antegrade perfusion (14.5—4% of slow wave frequency; P < 0.01). These results suggest that the reversal of small bowel segments in the treatment of the short bowel syndrome can result in an increase in absorption from the reversed segment itself in addition to any effect from delayed transit in the proximal bowel.