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The influence of total hepatectomy on cerebral energy state, ammonia‐related amino acids of the brain and plasma amino acids in the rat
Author(s) -
HOLMIN T.,
AGARDH C.D.,
ALINDER G.,
HERLIN P.,
HULTBERG B.
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00090.x
Subject(s) - hepatectomy , glutamine , amino acid , phosphocreatine , medicine , endocrinology , chemistry , cerebral cortex , glutamate receptor , alanine , hepatic encephalopathy , hyperammonemia , biochemistry , biology , resection , surgery , energy metabolism , receptor , cirrhosis
. The influence of total hepatectomy on cerebral energy state, ammonia‐related amino acids of the brain tissue and plasma amino acids was studied in anaesthetized rats after total hepatectomy. The hepatectomy was performed with the aid of a microsurgical three‐stage procedure. In the first stage, division of the inferior vena cava was performed. In the second stage 4 weeks later a porta‐caval anastomosis was constructed, followed after 1 week by a total hepatectomy. The brain energy state, defined as the concentrations of phosphocreatine, ATP, ADP and AMP, was unchanged 4 h after the hepatectomy. Plasma amino acids did not differ significantly between hepatectomized and shunted control rats. On the other hand, clear‐cut increases in the concentrations of glutamine, and decreases in the concentrations of glutamate and aspartate, were observed in the fronto‐parietal part of the cerebral cortex and the brain stem. These changes might explain the minor manifestations of cerebral dysfunction in the early phase of the hepatectomized state.