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The urinary excretion of prostaglandins E 2 and F 2 α in essential hypertension
Author(s) -
RATHAUS MAURO,
KORZETS ZEEV,
BERNHEIM JACQUES
Publication year - 1983
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1983.tb00058.x
Subject(s) - essential hypertension , medicine , endocrinology , prostaglandin e , excretion , pathogenesis , prostaglandin , urinary system , prostaglandin e2 , renin–angiotensin system , blood pressure
. The 24 h urinary excretions of prostaglandins E 2 (E 2 /d) and F 2 α (F 2 α/d) were measured in twenty‐five normal subjects and in thirty‐five patients with essential hypertension [seventeen with low renin (LRH) and eighteen with normal renin (NRH) hypertension]. E 2 /d was lower in patients with LRH than in normal subjects ( P <0.01), whereas no difference was found between patients with NRH and the controls. F 2 α/d was similar in patients with LRH and in the normal subjects, but was significantly greater in patients with NRH ( P <0.02). The ratio of prostaglandin E 2 to prostaglandin F 2 α was decreased in hypertensive patients ( P < 0.02), although in the NRH subgroup the difference was not statistically significant. It appears that LRH is associated with impaired production of prostaglandin E 2 , while a deranged relationship between the two prostaglandins exists in all the patients with essential hypertension. These changes in prostaglandin production could possibly contribute to the pathogenesis of hypertension, by increasing renal vascular resistance and decreasing sodium excretion. Alternatively, they might be a secondary phenomenon, reflecting changes in renal prostaglandin metabolism induced by the hypertensive state.