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Changes in splanchnic blood flow in portal hypertensive rats
Author(s) -
BLANCHET LAURENCE,
LEBREC DIDIER
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb02240.x
Subject(s) - splanchnic , splanchnic circulation , portal hypertension , medicine , blood flow , hemodynamics , portal venous pressure , portal vein , cardiology , liver circulation , endocrinology , cirrhosis
. This study was undertaken to assess splanchnic blood flow in rats with portal hypertension induced by portal vein stenosis. Splanchnic blood flow, estimated by the microsphere method, was significantly higher in portal hypertensive rats than in sham‐operated rats: 26·5±3·9 (mean ±SD) and 17·5±3·3 ml/min, respectively ( P <0·001). Hepatic blood flow, estimated by the clearance method, was significantly lower in portal hypertensive rats than in sham‐operated rats: 12·7±1·1 and 17·3±2·8 ml/min, respectively ( P <0·001). It is concluded that splanchnic blood flow is increased in rats with portal hypertension and that hepatic blood flow is different from splanchnic blood flow in these portal hypertensive rats. It is hypothesized that splanchnic blood flow may also be increased in patients with portal hypertension.