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Erythrocyte deformability in dialysed and non‐dialysed uraemic patients
Author(s) -
INAUEN W.,
STÄUBLI M.,
DESCOEUDRES C.,
GALEAZZI R. L.,
STRAUB P. W.
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb00955.x
Subject(s) - renal function , dialysis , filtration (mathematics) , creatinine , medicine , erythrocyte deformability , endocrinology , kidney disease , chemistry , urology , red blood cell , statistics , mathematics
. In thirty‐one uraemic patients, fourteen on conservative treatment and seventeen on long‐term haemodialysis, erythrocyte deformability, measured as filtration half‐time in a paper filtration experiment, was studied. The two groups were comparable concerning age, sex and kidney disease. Although the mean filtration half‐time for erythrocyte suspensions was normal in non‐dialysed patients there was a positive linear correlation ( P <0.01) between serum creatinine and filtration half‐time in this group. Filtration half‐time was increased in dialysed patients, indicating impaired deformability in the latter ( P <0.001). Filtration half‐time showed a good inverse correlation with the packed red cell volume in the non‐dialysed ( P <0.001) and in the dialysed group ( P <0.01). As pre‐ and post‐dialysis filtration half‐times were the same, it appeared that the more severe uraemic state of dialysed patients was responsible for the impairment of erythrocyte deformability and not the dialysis procedure itself.