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Mercuric chloride induced autoimmune disease in Brown‐Norway rats: sequential search for anti‐basement membrane antibodies and circulating immune complexes
Author(s) -
BELLON BLANCHE,
CAPRON MARTINE,
DRUET ELVIRA,
VERROUST P.,
VIAL MARIECÉCILE,
SAPIN CATHERINE,
GIRARD J. F.,
FOIDART J. M.,
MAHIEU P.,
DRUET P.
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb00949.x
Subject(s) - basement membrane , glomerular basement membrane , immune system , antibody , autoimmune disease , immune complex , immunology , glomerulonephritis , spleen , kidney , chemistry , biology , endocrinology , medicine , pathology
. Mercuric chloride induces in the Brown‐Norway rat a biphasic autoimmune disease characterized initially by linear IgG deposits along the glomerular basement membrane followed later by granular IgG deposition. In the present study, anti‐glomerular basement membrane antibodies and immune complex‐like material were sequentially assessed in serial serum samples. Both were transiently found at the same period. Glomerular linear IgG deposits were present on day 11 but circulating anti‐glomerular basement membrane antibodies were only found later on day 16. Circulating immune complexes were first detectable on day 8 before the earliest granular IgG deposits were first observed in the spleen vessels on day 16. The disappearance of circulating anti‐glomerular basement membrane antibodies and of circulating immune complexes, although HgCl 2 injections were pursued, is in agreement with the self‐limited character of mercuric chloride induced autoimmune disease and suggests the induction of immunosuppressive mechanisms.