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Relationships between the metabolism of high‐density and very‐low‐density lipoproteins in man: studies of apolipoprotein kinetics and adipose tissue lipoprotein lipase activity
Author(s) -
MAGILL P.,
RAO S. N.,
MILLER N. E.,
NICOLL A.,
BRUNZELL J.,
HILAIRE J. ST.,
LEWIS B.
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb00947.x
Subject(s) - adipose tissue , lipoprotein lipase , endocrinology , medicine , metabolism , lipase , lipid metabolism , apolipoprotein b , high density lipoprotein , chemistry , enzyme , biology , biochemistry , cholesterol
. In order to gain further insight into the relationship between high‐density lipoprotein (HDL) metabolism and plasma triglyceride transport, measurements were made of HDL cholesterol concentration, apoprotein (apo) AI and AII metabolism, very‐low‐density lipoprotein (VLDL) apo B metabolism, and heparin‐elutable adipose tissue lipoprotein lipase (LPL) activity in seventeen subjects with a wide range of plasma triglyceride concentrations (0.8–25 mmol/l). The fractional catabolic rate (FCR) of VLDL apo B was directly related to LPL activity ( r =+ 0.80), providing evidence that the activity of the enzyme in adipose tissue is a determinant of the rate of lipolysis of VLDL in man. HDL cholesterol concentration was a positive function of both VLDL apo B FCR ( r =+ 0.74) and LPL activity, a finding consistent with previous evidence for the origin of a proportion of HDL cholesterol from ‘surface remnants’ liberated during VLDL catabolism. The FCRs of both apo AI and apo AII were inversely related to VLDL apo B FCR (AI, r = ‐ 0.52; AII, r = ‐ 0.69) and to LPL activity. The synthetic rate of apo AII, but not that of apo AI, was positively correlated with VLDL apo B synthesis ( r =+ 0.71). Thus, the metabolism of the major proteins of HDL in man appears to be closely associated with VLDL metabolism.