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Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man
Author(s) -
BJÖRNSSON Ó. G.,
MATON P. N.,
FLETCHER D. R.,
CHADWICK V. S.
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb00945.x
Subject(s) - perfusion , secretin , medicine , indocyanine green , duodenum , endocrinology , gastroenterology , gallbladder , bicarbonate , excretion , secretion , pancreatic juice , chemistry , pancreas , pathology
. The effects of intraluminal sodium taurocholate (STC) on biliary and pancreatic secretion were studied in man using a duodenal perfusion technique and indocyanine green (ICG) as an exogenous biliary marker. Duodenal perfusion with 15 or 30 mmol/l STC in healthy subjects markedly suppressed caerulein and secretin stimulated biliary indocyanine green (ICG) excretion in a dose responsive manner, i.e. to 40% (17–95%, ± 2 SD, n = 5) ( P < 0.025) and 32% (26–38%, ± 2 SD, n = 3) ( P < 0.003) of i.v. ICG infusion, respectively, with a maximum suppression to 26% and 10%, respectively. In cholecystectomized subjects ( n = 5), significant changes in ICG excretion were not observed during STC (15 mmol/l) perfusion. There were no suppressive effects on pancreatic enzyme or bicarbonate secretion in any of the subjects. Our observations suggest that the bile salt STC in the duodenum in man activated a mechanism which selectively suppressed biliary excretion. This is probably due to relaxation of the gallbladder and an increase in gallbladder storage of bile.