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The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases
Author(s) -
HENRIKSEN LEIF,
PAULSON OLAF B.,
LAURITZEN MARTIN
Publication year - 1982
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1982.tb00684.x
Subject(s) - sodium nitroprusside , cerebral blood flow , anesthesia , pco2 , medicine , blood pressure , venous blood , hemodynamics , arterial blood , oxygen , blood flow , mean arterial pressure , heart rate , cardiology , chemistry , nitric oxide , organic chemistry
. Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133 Xe intra‐arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1·0 mg, mean infusion time 20 min), which reduced mean arterial blood pressure by a mean of 17%, resulted in a 13% decrease in CBF ( P <0·05). Measurements obtained 5 and 20 min after termination of the sodium nitroprusside infusion showed no signs of a hyperaemic rebound effect. Arterial PCO 2 , metabolic rate of oxygen, arterio‐venous oxygen difference and venous PO 2 remained unchanged during and after infusion. It is concluded that sodium nitroprusside has a minor effect on cerebral haemodynamics, an effect that might be mediated by the sympathetic nervous system.