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Effect of parenteral hyperalimentation on serum lipoproteins and on lipoprotein lipase activity of adipose tissue and skeletal muscle
Author(s) -
TASKINEN MARJARIITTA,
TULIKOURA ILKKA,
NIKKILÄ ESKO A.,
EHNHOLM CHRISTIAN
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb02123.x
Subject(s) - medicine , endocrinology , lipoprotein lipase , adipose tissue , parenteral nutrition , triglyceride , skeletal muscle , very low density lipoprotein , lipoprotein , chemistry , cholesterol
. This study reports on the effects of parenteral nutrition with glucose alone or in combination with Intralipidr̀ on heparin‐releasable lipoprotein lipase (LPL) activity of adipose tissue and skeletal muscle and on serum lipoproteins. Thirteen patients with postoperative hypercatabolism and nine patients with caloric malnutrition were studied. The average adipose tissue LPL activity increased 5‐fold during 4‐day glucose infusion (P < 0.001) and 7.4‐fold during Intralipidr̀ plus glucose infusion (P< 0.001). In contrast, no change occurred in the LPL activity of skeletal muscle. Glucose infusion caused a significant increase in VLDL and LDL triglyceride concentrations and the Intralipidr̀ plus glucose infusion was followed by a rise in LDL and HDL triglyceride concentrations. HDL cholesterol decreased by 26% (P < 0.01) during glucose and by 19% (P< 0.05) during Intralipidr̀ plus glucose. Apoprotein A I was very low already at the start of parenteral alimentation and it did not change during either nutrition. The HDL cholesterol and apoprotein A I and A II levels were each positively correlated with adipose tissue LPL activity before parenteral nutrition but not after it.