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Effect of indomethacin upon angiotensin‐induced changes in blood pressure and plasma aldosterone in normal man
Author(s) -
VIERHAPPER H.,
WALDHAUSL W.,
NOWOTNY P.
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb02044.x
Subject(s) - aldosterone , angiotensin ii , medicine , endocrinology , renin–angiotensin system , chemistry , endogeny , plasma renin activity , blood pressure , angiotensin iii , angiotensin receptor
. The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium‐repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg ‐1 min ‐1 ), whereas the pressor response to angiotensin II and to succinamyl 1 ‐val 5 ‐phenylglycine‐acetate 8 ‐angiotensin II, an agonistic angiotensin II‐analogue, was increased. Plasma renin concentration was reduced following treatment with indomethacin. These data confirm the modulatory influence of endogenous prostaglandins upon the vasoconstrictor effect of angiotensin II and could suggest a direct interference of prostaglandins with the secretion of aldosterone.