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Quantitative liver functions after 70% hepatectomy
Author(s) -
YILDIRIM S. I.,
POULSEN H. E.
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb02015.x
Subject(s) - hepatectomy , galactose , liver regeneration , liver function , endoplasmic reticulum , liver cell , cytosol , medicine , chemistry , endocrinology , biochemistry , biology , regeneration (biology) , surgery , resection , microbiology and biotechnology , enzyme
. Following 70% hepatectomy on rats the galactose elimination capacity, taken as a measure of the cytosolic liver function, was reduced from 2.55 ± 0.48 to 1.27 ± 019 (mean ± < SEM) μmol/min. Six hours later it was restored to control values. The prothrombin index, representing the function of the endoplasmic reticulum, was reduced from 1.13±0.02 to 0.34 ± 0.02 (arbitrary units) after 12 h, and it was restored after 96 h. The rapid normalization of the initial fall in the capacity to metabolize galactose reflects a two‐ to three‐fold increase of the galactose metabolizing capacity of the remaining liver. This study demonstrates that liver functions are dissociated in time following 70% hepatectomy in the rat, and that the galactose elimination capacity is restored before regeneration can compensate for the loss in liver cell mass.