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High density lipoprotein and other lipoproteins in normolipidaemic and hypertriglyceridaemic (type IV) men with coronary artery disease
Author(s) -
MOBERG B.,
WALLENTIN L.
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb02010.x
Subject(s) - coronary artery disease , medicine , percentile , risk factor , cholesterol , high density lipoprotein , endocrinology , lipoprotein , cardiology , gastroenterology , mathematics , statistics
. The aim was to investigate whether a low concentration of high density lipoprotein (HDL) may be used as a risk indicator in normolipidaemic (n.l.) subjects, and whether a reduced HDL concentration constitutes an additional risk factor in hyperlipopro‐teinaemia. Eighty‐two men with angiographically documented coronary artery disease (CAD) were studied. The majority of the CAD men was either n.l. ( n = 38) or had type IV hyperlipoproteinaemia ( n = 22). These two groups were compared separately to one group of healthy n.l. subjects ( n = 44), and one group of healthy subjects with type IV hyperlipoproteinaemia ( n = 29). In about 50% of n.l. CAD men the HDL‐cholesterol (HDL‐C) was lower than the 15th percentile (0.90 mmol/1) of n.l. controls, and about 65% of n.l. CAD men had ratios of HDL‐C/total plasma cholesterol (C) lower than 0.17, the 15th percentile of n.l. controls. Almost all type IV subjects had reduced HDL‐C levels and decreased ratios of HDL‐C/C, whether they had obvious CAD or not. Thus, in normolipidaemia, but not in type IV hyperlipoproteinaemia, a low HDL‐C level may be used as an additional risk factor for CAD development.