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Gastro‐entero‐pancreatic hormones in normal pregnancy: response to a protein rich meal
Author(s) -
HORNNES PETER J.,
KÜHL CLAUS,
LAURITSEN KELD B.
Publication year - 1981
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1981.tb01994.x
Subject(s) - medicine , endocrinology , glucagon , gastric inhibitory polypeptide , pancreatic polypeptide , gastrin , pregnancy , insulin , pancreatic hormone , hormone , peptide hormone , meal , glucagon like peptide 1 , ingestion , biology , diabetes mellitus , insulin resistance , type 2 diabetes , secretion , genetics
. The plasma concentrations of gastrin, gastric inhibitory polypeptide (GIP), gut glucagon‐like‐immunoreactivity (gut GLI), insulin, glucagon, and pancreatic polypeptide (PP) were studied following the ingestion of a protein rich meal in late pregnancy and postpartum in 11 normal women. In pregnancy, the fasting plasma concentrations of glucose (mean ± SEM in pregnancy: 4.1 ± 0.1 mmol1 ‐1 , postpartum: 4.7 ± 0.1 mmol1 ‐1 , p<0.01), gut GLI (25± 3 v. 33± 2 pmol‐eqv 1 ‐1 , P<0.01) and PP (7.9 ± 1.0 v. 13.0± 1.2 pmol 1 1 , P<0.01) were decreased, gastrin and GIP unaltered, and insulin (90± 9 v. 72 ± 5 pmol 1 1 , P<005) and glucagon (17±1 v. 13 ± 1 pmol 1 ‐1 , P<0.01) increased. The gastrin, GIP and glucagon responses to the meal were unaffected by pregnancy, whereas the responses of gut GLI (integrated responses in pregnancy: 1217 ± 325 pmol‐eqv 1 ‐1 postpartum 2223± 404 pmol‐eqv 1 ‐1 , P<005) and PP (9801 &± 1440 v. 14,078 ± 1543 pmol 1 ‐1 , P<001) were impaired and the insulin response enhanced (27,973 ± 6814 v. 11,409 ± 3102 pmol 1 ‐1 , P<001) in pregnancy. The physiological implications of these findings are at present not known in detail. They may, however, be important for the altered carbohydrate metabolism in pregnancy and also for the changes occurring during gestation in gastrointestinal physiology.