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Influence of renal denervation on urine concentration in awake and anaesthetized dogs
Author(s) -
KURKUS J.,
SADOWSKI J.,
GELLERT R.,
KRUŚ S.,
ZWOLIŃSKA J.
Publication year - 1980
Publication title -
european journal of clinical investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.164
H-Index - 107
eISSN - 1365-2362
pISSN - 0014-2972
DOI - 10.1111/j.1365-2362.1980.tb02086.x
Subject(s) - diuresis , denervation , kidney , mannitol , chemistry , urine , endocrinology , medicine , natriuresis , organic chemistry
. The role of renal nerves in urine concentration was studied in clearance experiments with unilaterally renal‐denervated dogs prepared by surgical bladder division. Urine concentration was assessed under conditions of: (1) stimulation of ADH release by dehydration or barbiturate anaesthesia; (2) mannitol diuresis, and (3) isotonic saline diuresis. Differences in TH‐.O/GF'R between the intact and denervated kidney were not significant in any of the experimental groups. However, in dehydrated conscious dogs U osm of the intact kidney (939 ± 58 mmol/kg H 2 O) was significantly higher ( P < 0.05) than that of the denervated organ (806 ± 51 mmol/kg H 2 O). In the intact kidney the medullary content of total solutes and sodium per kg wet tissue was 684 ± 26 mmol and 208 ± 12 mmol, respectively. This was significantly higher ( P < 0.005) than corresponding values of 581 ± 23 mmol and 171 ± 14 mmol per kg wet tissue measured in the denervated organ. We suggest that a slight impairment of urine concentration (lower U osm ) in the denervated kidney of conscious dogs may depend on decreased medullary hypertonicity.